Valentina BORGHESANI - Admise au titre de docteur

valentina_borghesani@hotmail.com
En recherche d'emploi
Disponibilité : mai 2018
Mobilité : Tous les pays

Projet professionnel :

enseignant-chercheur, enseignant du supérieur
chercheur en milieu académique
chercheur en entreprise, R&D du secteur privé
médiation scientifique, communication et journalisme scientifique, édition scientifique, relations internationales

Techniques maîtrisées :
- Proficient in monitoring the kinetics of aggregation of Amyloid-β peptide in presence of metal ions, as Zn(II) and Cu(II), by Fluorescence spectroscopy. - Exporting the competence acquired in the aggregation monitoring to optimization a system for monitoring the peptide aggregation by Cyclic Voltammetry. - Able to work independently on Cyclic Voltammetry. - Photophysical study of new marker able to monitoring the aggregation of peptide by UV-Vis spectroscopy or by Fluorescence with potential biologically compatibility. - Good command of imaging Amyloid-β aggregates by Atomic Force Microscopy and Transmission Electronic Microscopy and purifying Amyloid-β peptide by Fast Protein Liquid Chromatography and its condition optimization. - Proficient use of Microwave Peptide Synthesizer and deprotection of synthetic peptide and their purification by HPLC. -Use of principal laboratory techniques as UV-Vis, Fluorimeter, IR spectroscopy, Cyclic Voltammetry, 1H-NMR, 13C-NMR, TEM, AFM, SPPS. -Good command of the technical software ChemDraw, KaleidaGraph, OriginLab, SPSS, OriginLab, Hyperquad, PyMol, MestReNova.
Compétences :
- Proficient in the scientific results communication - Creative and team-oriented individual with a passion for helping - Highly motivated and able to lead a project independently - Able to explain clearly scientific subject to unskilled audience and conduct popularization scientific activities in schools and during events (ex. European Researchers’ Night etc.)

Doctorat Chimie-Biologie-Santé

Thèse soutenue le 13 avril 2018 - Université de Toulouse

Ecole doctorale : SDM - SCIENCES DE LA MATIERE - Toulouse

Sujet : Impact des ions zinc et cuivre dans la cascade amyloïde liée à la maladie d'Alzheimer

Mots-clés de la thèse : chimie bioinorganique,Zinc,peptides,Maladie d'Alzheïmer,cuivre,ERO,

Direction de thèse : Christelle HUREAU-SABATER

Unité de recherche : LCC - Laboratoire de Chimie de Coordination UPR 8241 - Toulouse

Diplôme étranger - Master Recherche

obtenu en décembre 2014 - Università degli studi di Parma
Option : Biomolecular Chemistry

Production scientifique

- Borghesani, V., Alies, B. and Hureau, C. 2018. CuII Binding to Various Forms of Amyloid-β Peptides: Are They Friends or Foes? Eur. J. Inorg. Chem., 1/2018 page 7–15, http://onlinelibrary.wiley.com/doi/10.1002/ejic.201700776/full
- Valentina Borghesani, Bruno Alies and Christelle Hureau 2018. Front Cover: CuII Binding to Various Forms of Amyloid-β Peptides: Are They Friends or Foes? Eur. J. Inorg. Chem., 1/2018 page 1, http://onlinelibrary.wiley.com/doi/10.1002/ejic.v2018.1/issuetoc
- A. Conte-Daban#, V. Borghesani#, S. Sayen, E. Guillon, Y. Journaux, G. Gontard, L. Lisnard, C. Hureau 2017. Link between Affinity and Cu(II) Binding Sites to Amyloid-β Peptides Evaluated by a New Water Soluble UV-Visible Ratiometric Dye with a Moderate Cu(II) Affinity anal.Chem., 89,2155-2162,
- M. Del Barrio, V. Borghesani, C. Hureau, P. Faller 2017. Metal-Binding to Amyloid-β Peptide: Coordination, Aggregation, and Reactive Oxygen Species Production. Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics, 276-278,
- Luciano Marchiò, Nicola Marchetti, Corrado Atzeri, Valentina Borghesani, Maurizio Remelli and Matteo Tegoni* 2014. The peculiar behavior of Picha in the formation of metallacrown complexes with Cu(II), Ni(II) and Zn(II) in aqueous solution Dalton Trans., Dalton Trans., 2015, issue 7, 44, 3237-3250, http://pubs.rsc.org/en/Content/ArticleLanding/2015/DT/C4DT03264K#!divAbstract

Dernière mise à jour le 20 juin 2018