Omar SADEK - Admis au titre de docteur


Adresse Professionnelle
Equipe CP3A, ICMMO, 17 avenue des Sciences 91400
ORSAY FRANCE
omar.m.a.sadek@gmail.com

Expérience professionnelle :
Fonctionnaire
Domaine d'activité : Synthèse organique, procédés écocompatibles en flux continu
Type de contrat : Maître de conférences
Fonction exercée : Maître de conférences
Secteur d'emploi : Recherche-développement en sciences physiques et naturelles
Unité de recherche ou entreprise : Institut de Chimie Moléculaire et des Matériaux d'Orsay
Orsay - FRANCE

Doctorat Chimie Moléculaire


Thèse soutenue le 4 octobre 2018 - Université de Toulouse

Ecole doctorale : SDM - SCIENCES DE LA MATIERE - Toulouse

Sujet : Exploitation du couple Bore-Fluor pour la fluoration et la synthèse d'agents d'imagerie bimodaux potentiels

Mots-clés de la thèse : bore,fluor,fluorination,fluorophores,organotrifluoroborates,

Direction de thèse : Emmanuel GRAS

Co-direction de thèse : David Perrin

Cotutelle The University of British Columbia CANADA
Descriptif : Dr. Gras and Dr. Perrin share joint interests in manipulating, reacting and incorporating radioactive fluorine atoms (18F) into biomolecules. Our global strategy is to use boron as a carrier of 18F-fluoride in the formation of a trifluoroborate radioprosthetic and/or as an intermediary in delivering fluoride to an organic substrate via anion or radical abstraction mechanism. Both UBC Chemistry department and the LCC (Laboratoire de Chimie de Coordination) in Toulouse, where Dr. Perrin and Dr. Gras hold permanent research positions are well-known for multidisciplinary work at the interface of biochemsitry, bioorganic and bioinorganic chemistry. Based on our respective interests and expertise, our joint effort in which Mr. Sadek serves as a nexus, provide Mr. Sadek with a unique opportunity to increase his knowledge and technical skills in applications of chemistry to radiotracer and drug development.

Unité de recherche : LCC - Laboratoire de Chimie de Coordination UPR 8241 - Toulouse

Diplôme étranger - Bachelor of Science

obtenu en mai 2013 - The University of British Columbia
Option : Chemistry

Production scientifique

- Alexandre Porcheron, Omar Sadek, Salem Ba Sowid, Nathalie Bridonneau, Laura Hippolyte, Dimitri Mercier, Philippe Marcus, Lukmonjon Mutalliev, Clément Chauvier, Corinne Chanéac, Louis Fensterbank, François Ribot 2023. Direct Synthesis of Mesoionic Carbene (MIC)-Stabilized Gold Nanoparticles from 1,2,3-Triazolium Salts   Chemistry of Materials, 35, pp.6865-6876, https://hal.science/hal-04185135/document
- Laura Hippolyte, Omar Sadek, Salem Ba Sowid, Alexandre Porcheron, Nathalie Bridonneau, Sébastien Blanchard, Marine Desage-El Murr, David Gatineau, Yves Gimbert, Dimitri Mercier, Philippe Marcus, Clément Chauvier, Corinne Chanéac, François Ribot, Louis Fensterbank 2023. N-Heterocyclic Carbene Boranes: Dual Reagents for the Synthesis of Gold Nanoparticles   Chemistry - A European Journal, 29, pp.e202301610, https://hal.science/hal-04116921/document
- Omar Sadek, Jad Rabah, Dimitri Mercier, Philippe Marcus, Clément Chauvier, François Ribot, Louis Fensterbank, Emmanuel Maisonhaute 2023. Tailored Functional Monolayers Made from Mesoionic Carbenes   , , https://hal.sorbonne-universite.fr/hal-04250305/document
- Omar Sadek, Arnaud Le Gac, Nereida Hidalgo, Sonia Malletladeira, Karinne Miqueu, Ghenwa Bouhadir, Didier Bourissou 2022. MetalFree PhosphorusDirected Borylation of C(sp2)H Bonds   Angewandte Chemie International Edition, 61, pp.e202110102, https://hal.science/hal-03509543/document
- Omar Sadek, Mehdi Abdellaoui, Alexandre Millanvois, Cyril Ollivier, Louis Fensterbank 2022. Organometallic catalysis under visible light activation: benefits and preliminary rationales   Photochemical & Photobiological Sciences, 21, pp.585-606, https://hal.science/hal-03872899/document
- Omar Sadek, Laura Abad Galán, Frédéric Gendron, Bruno Baguenard, Stephan Guy, Amina Bensalah, Boris Le Guennic, Olivier Maury, David M Perrin, Emmanuel Gras 2021. Chiral Benzothiazole Monofluoroborate Featuring Chiroptical and Oxygen-Sensitizing Properties: Synthesis and Photophysical Studies   Journal of Organic Chemistry, 86, pp.17, https://hal.science/hal-03333839/document
- Omar Sadek, Ghenwa Bouhadir, Didier Bourissou 2021. Lewis Pairing and Frustration of Group 13/15 Elements Geometrically Enforced by (Ace)Naphthalene, Biphenylene and (Thio)Xanthene Backbones   Chemical Society Reviews, 50, pp.5777-5805, https://hal.science/hal-03430133/document
- Omar Sadek, David Perrin, Emmanuel Gras 2020. Straightforward convergent access to 2-arylated polysubstituted benzothiazoles   Tetrahedron, 76, pp.130982, https://hal.science/hal-02611196/document
- Omar Sadek, David Perrin, Emmanuel Gras 2019. Unsymmetrical diaryliodonium phenyltrifluoroborate salts: Synthesis, structure and fluorination   Journal of Fluorine Chemistry, 222-223, pp.68-74,
- Mohy El Dine, T.,+ Sadek, O.,+ Gras, E., Perrin, D. M. 2018. Expanding the Balz-Schiemann Reaction: organotrifluoroborates serve as competent sources of fluoride ion for fluoro-dediazoniation.   Chemistry - A European Journal, https://doi.org/10.1002/chem.201803575, https://doi.org/10.1002/chem.201803575
- Tharwat Mohyeldine, Omar Sadek, Emmanuel Gras, David M. Perrin 2018. Expanding the BalzSchiemann reaction: Organotrifluoroborates serve as competent sources of fluoride Ion for fluoro-dediazoniation   Chemistry - A European Journal, 24, pp.14933-14937,
- Omar Sadek 2018. Exploiting boron-fluorine bonds for fluorination and synthesis of potential bi-modal imaging agents Exploitation du couple bore-fluor pour la fluoration et la synthèse d'agnet d'imagerie bimodaux potentiels   , , https://theses.hal.science/tel-02146608/document
- Duo Wei, Omar Sadek, Vincent Dorcet, Thierry Roisnel, Christophe Darcel, Emmanuel Gras, Eric Clot, Jean-Baptiste Sortais 2018. Selective mono N-methylation of anilines with methanol catalyzed by rhenium complexes: An experimental and theoretical study   Journal of Catalysis, 366, pp.300 - 309,
- Wei, D., Sadek, O., Dorcet, V., Roisnel, T., Darcel, C., Gras, E., Clot, E., Sortais, J.-B. 2018. Selective mono N-methylation of anilines with methanol catalyzed by rhenium complexes: an experimental and theoretical study.   Journal of Catalysis, pending,
- Daniel Pla, Omar Sadek, Sarah Cadet, Béatrice Mestre-Voegtlé, and Emmanuel Gras 2015. Naphthylaminoborane: from structural switches to frustrated Lewis pair reactivity   Dalton Transactions, Vol. 44, pg. 18340-18346, http://dx.doi.org/10.1039/C5DT02659H
- Daniel Pla, Omar Sadek, Sarah Cadet, Béatrice Mestre-Voegtlé, Emmanuel Gras 2015. Naphthylaminoborane: from structural switches to frustrated Lewis pair reactivity   Dalton Transactions, 44, pp.18340-18346,
Dernière mise à jour le 29 avril 2024