Tetiana MATVIIUK - Soutenance en cours de traitement

Projet professionnel :

Design, synthesis and evaluation of biological activity of InhA inhibitors as well as Mycobacterium tuberculosis inhibitors

Expérience professionnelle :
CDI
Fonction exercée : Enseignant-chercheur
Sujet de recherche ou mission professionnelle :Enseignant-chercheur, Université Taras Schevchenko, Kiev (Ukraine)
Unité de recherche ou entreprise : Université Taras Schevchenko
Kiev - UKRAINE

Doctorat Chimie-Biologie-Santé

Thèse soutenue le 16 juin 2014 - Université de Toulouse

Ecole doctorale : SDM - SCIENCES DE LA MATIERE - Toulouse

Sujet : Reaction de couplage,synthese des systemes (poly, hetero) aromatiques et evaluation en tant qu inhibiteurs d'InhA enzyme essentielle de Mycobacterium Tuberculosis

Mots-clés de la thèse : inhibiteurs d'InhA,reaction de couplage,Mycobacterium Tuberculosis,systems hetero aromatiques,Michael addition,succinimide

Direction de thèse : Michel BALTAS

Co-encadrement de thèse : Zoia VOITENKO

Cotutelle Universite National Tarass Chevtchenko de Kiev UKRAINE
Descriptif : Candidates preparing a joint supervision doctorate have to meet the conditions of admission in thesis in both universities. Registration fees are charged in one university only. Candidates have to possess social security cover and individual insurance valid in each of the two countries. The conditions of accommodation and financial support to mobility will be precised in the special clauses of the convention. Doctoral students do their research work under the control and responsibility of a thesis supervisor in each of the two institutions. The two supervisors agree to carry out their function of tutor of the doctoral student. The Doctoral School director commits to enforce the rules of his Doctoral School. The time for preparation of the thesis will be shared alternately and in balanced periods between the two institutions. The thesis will terminate with a single viva voce examination, the result of which will be recognized by the two institutions. The viva voce examining board jointly designated by the two universities will be equally composed of members from each institution and will besides consist of persons exterior to the universities. The members of the board cannot exceed the number of eight. The language in which the thesis is written is defined in the special clauses of this convention. If the language is not French, the thesis will be completed by a substantial summary in French or Enghish. Following success in the viva voce examination, and considering the examination report, the two universities will award, either separately or jointly, the diploma of Doctor. The diploma has to mention of name of speciality or field of study, the title of the thesis or name of the main research works, the mention of international joint supervision of thesis, the name and title of the members of the examination board, and the date of defence of the thesis.

Unité de recherche : SPCMIB - Laboratoire de Synthèse et PhysicoChimie de Molécules d'Intérêt Biologique UMR 5068 - Toulouse

Diplôme étranger - Chemistry

obtenu en mai 2009 - Universite National Taras Chevtchenko de Kiev
Option : organic chemistry

Production scientifique

- T. Matviiuk, G. Mori, C. Lherbet, F. Rodriguez, M. R. Pasca, M. Gorichko, B. Guidetti, Z. Voitenko, M. Baltas 2014. Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis European Journal of Medicinal Chemistry, Vol. 71, p. 46 – 52, http://dx.doi.org/10.1016/j.ejmech.2013.10.069
- T. Matviiuk, M. Baltas, Z. Voitenko, M. Gorichko and C. Lherbet 2013. 2-(9H-Fluoren-9-yl)-4-(4-fluoroanilino)-4-oxobutanoic acid Acta Crystallographica: section E, Vol. E69, p. o963, doi:10.1107/S1600536813013779
- T. V. Matviiuk, M. V. Gorichko, C. Lherbet, M. Baltas, Z. V. Voitenko. 2013. Carbon-carbon and carbon-heteroatom conjugate addition of N-substituted maleimides to 4H-1,2,4- triazol-3-thioles, 2-amino-1,3-thiazoles, 1H-imidazole and 2-phenylindolizine catalyzed by Lewis acids Journal of Organic and Pharmaceutical Chemistry., Vol. 11, № 3 (43), p. 36 – 42, http://nuph.edu.ua/wp-content/uploads/2013/10/ZHOFH_3_2013_36-42.pdf
- T. Matviiuk, F. Rodrigues, N. Saffon, S. Mallet-Ladeira, M. Gorichko, A.-L. de Jesus Lopes Ribeiro, M. R. Pasca, C. Lherbet, Z. Voitenko, M. Baltas. 2013. Design, chemical synthesis of 3-(9H-fluoren-9-yl)pyrrolidine- 2,5-dione derivatives and biological activity against enoyl-ACP reductase (InhA) and Mycobacterium tuberculosis European Journal of Medicinal Chemistry, Vol. 70. p. 37 – 48. , http://dx.doi.org/10.1016/j.ejmech.2013.09.041
- T. Matviiuk, M. Gorichko, A. Kysil, S. Shishkina, O. Shishkin, Z. Voitenko 2012. Catalysis by Lithium Perchlorate Enables Double-Conjugate Addition of Electron-Deficient Maleimides to 2-Aminopyridines and 2-Aminothiazoles Synthetic Communications, Vol. 42, № 22, p. 3304 – 3310, http://dx.doi.org/10.1080/00397911.2011.580883

Langues Vivantes : Anglais C2 - Courant - Russe C2 - Courant - Français A1 - Débutant - Ukrainien C2 - Maternel

Dernière mise à jour le 15 décembre 2014