About the Positions: The laboratory of Dr. Laurent Calvier located in the Department of Neurology at UT Southwestern Medical Center (Dallas, USA) is seeking a highly motivated, proactive, postdoctoral researcher to investigate neuroinflammatory and neurodegenerative diseases. The main project for these two positions are entitled “New communication axis from the brain to the peripheral immune system during Alzheimer’s disease” and ”COVID-19 and elevated plasma Reelin are risk factors for Alzheimer’s disease”, with a broader impact on other chronic inflammatory diseases and auto-immune diseases. Besides the main project, the candidate is expected to participate in other active projects in the lab, such as: Blood-brain barrier dysfunction; Neuroinflammation-induced neuronal dysfunction; Small molecule drug discovery and development; Antibody development and humanization.

About the Lab: Calvier lab focuses on unraveling the complexities of neurodegenerative diseases through the lens of inflammatory and vascular disorders. Their research has revealed the intriguing role of peripheral Reelin in regulating leukocyte migration across the bloodbrain barrier, with significant implications for neuroinflammatory diseases. The lab is also actively engaged in drug development aimed at clinical applications.

Qualifications:
• Ph.D. and/or M.D. degree in Neuroscience, Immunology, Vascular Biology, or related field.
• Expertise in routine molecular analysis techniques (Western blot, RT-qPCR, ELISA, IF, IHC).
• Experience with cell culture (endothelial cells, neurons, or iPSC)
• Proficiency in mouse handling and experiments.
• Excellent writing and presentation skills in English (expected to submit postdoctoral grants, high-impact research papers, and abstracts to conferences).

Optional (opportunities for skill development available):
• FACS, RNA sequencing (total, single-cell, spatial)
• Cloning, CRISPR-Cas9, gene therapy
• MRI, brain surgery, behavioral experiments on small animals
• 2-photon microscopy, Intravital microscopy
• In vitro endothelial-leukocyte adhesion and transmigration assays
• Neuron cell culture (primary and iPSC-derived)

How to Apply: Please send your CV, a brief statement of research interests, and a list of three references to Dr. Laurent Calvier email: laurent.calvier@utsouthwestern.edu.