BANQUE INTERNATIONALE DE SUJETS DE THESE

Ecole Doctorale : SEVAB - Sciences Ecologiques, Vétérinaires, Agronomiques et Bioingenieries

Impact of mobile genetic elements in Staphylococcus aureus on emergence and spread of antimicrobial resistance
n°9

Encadrant de thèse :
Emilie DORDET FRISONI
Adresse mail :
emilie.dordet-frisoni@envt.fr
Laboratoire de rattachement :
INTHERES - Innovations Thérapeutiques et Résistances
Adresse du site internet du laboratoire :
http://www.envt.fr
Directeur de laboratoire :
 Alain BOUSQUET-MELOU
Adresse mail :
 a.bousquet-melou@envt.fr
École Doctorale :
 EDSEVAB
PAYS :
Chine
Langue de la thèse :
francais ,anglais ,

Directeur de thèse :
Emilie DORDET FRISONI
Descriptif : Staphylococcus aureus is a commensal bacterium and a major opportunistic pathogen of humans and mammals. There are substantial quantities of antibiotic resistance (ARG) genes in this bacterial species. The transmission capacity of S. aureus ARG is closely associated with the high proportion of mobile genetic elements (MGEs) present in its genome and its ability to exchange genetic material with its environment. Few data are currently available on the diversity of MGEs carrying the determinants of resistance and the intrinsic mechanisms governing genetic exchanges in this species. The objective of this project is to establish a current mapping of S. aureus strains of animal origin (production and companion animals), of their MGEs and ARGs. In vitro tests will be performed to determine the privileged mechanisms of HGTs, their frequency, the MGEs involved, the type of ARGs exchanged and the impact of environmental factors such as the presence of antibiotics or the biofilm lifestyle

Publications relatives au sujet :
Broussou DC, Toutain PL, Woehrlé F, El Garch F, Bousquet-Melou A, Ferran AA. Comparison of in vitro static and dynamic assays to evaluate the efficacy of an antimicrobial drug combination against Staphylococcus aureus. PLoS One. 2019 Jan 23;14(1):e0211214. doi: 10.1371/journal.pone.0211214. PMID: 30673774; PMCID: PMC6344103
Dordet-Frisoni E, Sagné E, Baranowski E, Breton M, Nouvel LX, Blanchard A, et al. Chromosomal transfers in mycoplasmas: when minimal genomes go mobile. mBio. 2014;5(6):e01958.

Mots clés : Staphylococcus aureus ;Horizontal gene transfer ;Mobile genetic elements ;Antibioc resistance ;

Collaboration avec un laboratoire : INTHERES - Innovations Thérapeutiques et Résistances
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