BANQUE INTERNATIONALE DE SUJETS DE THESE

Ecole Doctorale : BSB - Biologie, Santé, Biotechnologies

Structural and functional characterization of new immunomodulators of Mycobacterium tuberculosis
n°105

Encadrant de thèse :
Emilie LAYRE
Adresse mail :
Emilie.Layre@ipbs.fr
Laboratoire de rattachement :
IPBS - Institut de Pharmacologie et Biologie Structurale
Adresse du site internet du laboratoire :
http://www.ipbs.fr
Directeur de laboratoire :
 Olivier NEYROLLES
Adresse mail :
 olivier.neyrolles@ipbs.fr
École Doctorale :
 EDBSB
PAYS :

Colombie
Mexique - discipline : Biotechnology
Langue de la thèse :
francais ,anglais ,

Directeur de thèse :
Emilie LAYRE

Site Internet : http://www.ipbs.fr/immunomodulation-mycobacterial-lipids-and-glycoconjugates
Descriptif : According to the WHO, Tuberculosis is one of the top 10 causes of death worldwide. M. tuberculosis (Mtb), which is an intracellular pathogen of alveolar macrophages, has evolved strategies to evade host immune responses. Mycobacteria distinguise by the biosynthesis of a diverse repertoire of lipids capable to potently regulate immune responses. However, this repertoire has been essentially characterized by studying bacteria broth cultures. Using last-generation lipidomic approaches (based on high sensitivity mass spectrometry), we performed global analysis of this repertoire in diverse conditions such as infection conditions. We have highlighted molecules of unknown structure and functions specifically produced by virulent Mtb strains, which represent potential important immunomodulators. This project aims at characterising the structure of such molecules using state-of-the-art tools and at deciphering their capabilty to regulate the functions of macrophages.

Publications relatives au sujet :
Layre E, et al. A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis. Chemistry & biology. 2011, 18(12):1537-49
) Neyrolles O, Guilhot C. Recent advances in deciphering the contribution of Mycobacterium tuberculosis lipids to pathogenesis. Tuberculosis. 2011; 91(3):187-95

Mots clés : tuberculosis ;lipidomic ;host-pathogen interaction ;mass spectrometry ;macrophages ;

Collaboration avec un laboratoire : IPBS - Institut de Pharmacologie et Biologie Structurale
Plus d'informations sur le sujet de thèse